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Female Infertility - Hidden Factors

Female Infertility - Hidden Factors

Female Infertility - Hidden Factors | In cases where the desired pregnancy is not achieved there is experience of recurrent pregnancies

In cases where the clinical examination by the gynecologist and the first fertility test as described on the "Menstruation & Fertility" page has no significant findings and

  1. the desired pregnancy is not achieved
  2. there is experience of recurrent pregnancies

Laboratory testing

The test checks the number and quality of chromosomes. Possible genital damage to the chromosomes makes natural pregnancy difficult and with serious health risks for the child to be born. In these cases, the contribution of a pre-implantation check from a specialized IVF center is required.

Immune dysfunctions from autoimmune diseases and mutations in specific genes that participate in the regulation of hemostasis are observed particularly often. These lead to an increased chance of blood clots in the new vessels of the endometrium – the area where the embryo is implanted. In case of the formation of clots in the new vessels, the flow of blood in the vessels of the uterus becomes difficult or interrupted and by extension the perfusion of the fetus, with possible problematic attachment - its development, or its miscarriage. The screening assesses the possible requirement of prophylactic antithrombotic therapy during pregnancy.

Complete thrombophilia screening is recommended, including:
  1. the biochemical-immunological control of thrombophilia especially in people who have autoimmune diseases themselves or their family members as described on the page "Thrombophilia"
  2. the thrombophilia gene test shows possible gene mutations that cause blood clots, especially in people with family members with strokes, heart attacks, and embolisms, as described on the "Thrombophilia gene" page

It is one of the important causes of infertility, where the endometrium develops in areas outside the uterus. The diagnosis of this condition is made by the method of choice, laparoscopy, which is, invasive. Laboratory testing can by detecting markers of ovarian inflammation CA-125 and the general immune marker of inflammation IL-6, and indicate the necessity or not of the laparoscopic examination of the ovaries

The classical cultures recommended for fertility control often have false negative results. Depending on the test and the test subject, the false negative results of cultures can reach up to 60%. However, in cases of unexplained infertility, in case of negative culture results, the confirmatory detection of ureaplasma, mycoplasma, and chlamydia, with the ultra-sensitive and most reliable molecular method of detecting their DNA, is recommended, as described in the "Sexually Transmitted Parasites" page.

Many reports have been made of infertility due to a lack of vitamins, especially in women with eating disorders - malabsorption problems - smokers. The most important in their lack are:

  1. Vitamin A
  2. Folic acid B9
  3. Vitamin B12
  4. Vitamin E

We recommend that these examinations be done gradually to reduce costs and with the advice and monitoring of the responsible gynecologist or obstetrician.

For more information about exams and preparation requirements, look for the relevant pages

Typically are mentioned the costs for laboratory testing:
  1. karyotype of a couple: 250 euros.
  2. high-resolution molecular karyotype (per person): 450 euros
  3. autoimmune thrombophilia about 100 euros
  4. genetic thrombophilia with full analysis in 20 genes: 180 euros.
  5. indicators of inflammation - endometriosis: 70 euros.
  6. the molecular detection of bacteria: 100 euros
  7. package of vitamin levels of Vitamins A, B12, E, and Folic acid: 80 euros

The results for the karyotype are given in 15 – 20 working days,

Genetic testing for thrombophilia in 10 working days and for the rest in 2-4 working days.

Information selected - indicative with sources: Interpretation of Diagnostic Tests - J.Wallach and

The choice and explanation of the use of the analysis is the exclusive responsibility of your doctor

Edited by : Ioannis Grattisia Head of Laboratory / MSc Clinical Biochemistry - Molecular Biology

2022 - 2023

Biopathology Diagnostic Laboratory | Microbiological | Molecular | DNA | Ultrasonic | EOPYY – Clinic

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