The test checks the number and quality of chromosomes. Possible genital damage to the chromosomes makes natural pregnancy difficult and with serious health risks for the child to be born. In these cases, the contribution of a pre-implantation check from a specialized IVF center is required.

Immune dysfunctions from autoimmune diseases and mutations in specific genes that participate in the regulation of hemostasis are observed particularly often. These lead to an increased chance of blood clots in the new vessels of the endometrium – the area where the embryo is implanted. In case of the formation of clots in the new vessels, the flow of blood in the vessels of the uterus becomes difficult or interrupted and by extension the perfusion of the fetus, with possible problematic attachment - its development, or its miscarriage. The screening assesses the possible requirement of prophylactic antithrombotic therapy during pregnancy.

Complete thrombophilia screening is recommended, including:

1. the biochemical-immunological control of thrombophilia especially in people who have autoimmune diseases themselves or their family members as described on the page "Thrombophilia"
2. the thrombophilia gene test shows possible gene mutations that cause blood clots, especially in people with family members with strokes, heart attacks, and embolisms, as described on the "Thrombophilia gene" page

It is one of the important causes of infertility, where the endometrium develops in areas outside the uterus. The diagnosis of this condition is made by the method of choice, laparoscopy, which is, invasive. Laboratory testing can by detecting markers of ovarian inflammation CA-125 and the general immune marker of inflammation IL-6, and indicate the necessity or not of the laparoscopic examination of the ovaries

The classical cultures recommended for fertility control often have false negative results. Depending on the test and the test subject, the false negative results of cultures can reach up to 60%. However, in cases of unexplained infertility, in case of negative culture results, the confirmatory detection of ureaplasma, mycoplasma, and chlamydia, with the ultra-sensitive and most reliable molecular method of detecting their DNA, is recommended, as described in the "Sexually Transmitted Parasites" page.

Many reports have been made of infertility due to a lack of vitamins, especially in women with eating disorders - malabsorption problems - smokers. The most important in their lack are:

1. Vitamin A
2. Folic acid B9
3. Vitamin B12
4. Vitamin E