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Celiac disease

What is this?

Celiac disease – is an autoimmune condition that causes gluten intolerance. It is superficial damage on the small intestine caused by the immune reaction mainly to the consumption of gluten. Gluten is a protein found in wheat, barley, rye, and other grains.


The damage caused to the intestine by gluten irritation can also cause problems with the body's ability to absorb many important nutrients, such as iron, and vitamin B12, which is why it is part of the analysis in the investigation of anemias.

Recently, celiac disease has also been associated with infertility for both men and women. Women can experience cycle abnormalities, even amenorrhea or early menopause, while men can experience low testosterone levels. There are many reports that celiac disease is a key factor in infertility.

Among the severe clinical symptoms presented are stomach cramps, bloating, cachexia, anemia, and diarrhea.

Laboratory indications for celiac disease are unexplained low levels of iron and vitamin B12 and possibly low hematocrit.


The tests used in the detection of celiac disease:

  1. Reticulin IgA antibodies
  2. IgA-IgG antigliadin antibodies
  3. Antibodies against Intramuscular IgA-IgG
  4. Antibodies against Tissue Transglutaminase IgA-IgG

Gene tests, that are used in family members with a person with celiac disease, or in cases of autoantibody results are unclear, include

  1. HLA DQ2
  2. HLA DQ8

The tests, that are used to assess the anemia – inflammation – malabsorption, which are caused by celiac disease are

  1. Blood chart,
  2. Red sedimentation rate
  3. CRP
  4. Ferrum
  5. Ferritin
  6. Total ferrum binding capacity
  7. Folic Acid
  8. Vitamin B12
  9. Vitamin D3 25(OH)


A simple blood test is required for laboratory testing.

No preparation or diet is required.


Blood sampling can be done at any time of the day (the laboratory's working hours are 7.30 a.m. – 7.30 p.m.).


Autoantibody results are given within 3 working days.

DQ2 / DQ8 genes are given within 5-10 working days

The tests to assess anemia - inflammation - malabsorption, within the day


Autoantibodies and celiac effect tests are prescribed at the EOPYY, with the participation of the examinee as defined by the referral (15%, unless otherwise mentioned )

Gene DQ2 / DQ8 are NOT prescribed in EOPYY

The cost with private coverage is:
  • The complete check-up package of the total antibody measurement (7 antibodies) is on offer from 210 euros to 129 euros.
  • The measurement of DQ2/DQ8 is 125 euros.

Information selected - indicative with sources: Interpretation of Diagnostic Tests - J.Wallach and

The choice and explanation of the use of the analysis is the exclusive responsibility of your doctor

Edited by : Ioannis Grattisia Head of Laboratory / MSc Clinical Biochemistry - Molecular Biology

2022 - 2023

Biopathology Diagnostic Laboratory | Microbiological | Molecular | DNA | Ultrasonic | EOPYY – Clinic

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