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Chronic Fatigue Syndrome

What is this?

The symptoms of Chronic Fatigue Syndrome are intense exhaustion, poor sleep quality, waking up with headaches, musculoskeletal and joint pain, and memory problems. The intensity and type of symptoms vary from day to day.

Other signs may be, abdominal or chest pain, bloating, persistent cough, depression and anxiety, diarrhea, dizziness, dry eyes or mouth or ears, irregular pulse, jaw pain, nausea and loss of appetite, sweating during sleep, and breathing difficulties.


Investigating the situation includes detecting in

  • Common chronic diseases - conditions using the analyzes of the general check-up. Inflammatory markers as well as metabolic markers are used to rule out possible persistent immune activation or a significant metabolic disorder
  • Less common diseases that cause a feeling of fatigue. Thyroid dysfunction, autoimmune, trace element deficiency, and excessive chemical stress is among the cases, that are examined.

Tests, that are chosen, include:

General Check Up

Γενική αίματος / Αιμοδιάγραμμα CBCΜετρήσεις σε Αιματοκρίτη - Ερυθρά - Λευκά Αιμοσφαίρια - Αιμοπετάλια και εξέταση μορφολογίας τους.
Ανιχνεύονται κυρίως Αναιμίες, Φλεγμονές, Λοιμώξεις, Δυσπλασίες μυελού.
Ενδείξεις - επίδραση χρόνιων νοσημάτων - καταστάσεων
Ταχύτητα καθίζησης ΤΚΕ / ESR
C-αντιδρώσα πρωτεϊνη Υψηλής ευαισθησίας CRP-hs Βραχυχρόνιες κεντρικές αλλά και τοπικές φλεγμονές,
συνεκτίμηση καρδιαγγειακού κινδύνου από ενδοαγγειακές φλεγμονές
Σάκχαρο νηστείας / διώρου GluΣακχαρώδη διαβήτη / προδιάθεση σε διαβήτη
Ουρία UreaΝεφρική λειτουργία
Κρεατινίνη Cr
Ουρικό οξύ UAΑρθρίτιδες, διατροφικές διαταραχές
Χοληστερίνη Ολική CholΤην ποσότητα και αναλογία των λιπιδίων του αίματος ως
- βασικός δείκτης μακροχρόνιου κινδύνου σε καρδιαγγειακά
- δείκτη μεταβολικού προφίλ
Χοληστερίνη HDL
Χοληστερίνη LDL
Τριγλυκερίδια Tgl
Αθηρωματικός δείκτης
γ-γλουταμινοτρανσφεράση γ-GTΗπατική λειτουργία, πιθανή ενόχληση του ήπατος από χημικούς παράγοντες ή λοιμώξεις
Τρανσαμινάσες ALT & AST
Γενική ούρωνΠαθολογία και λοιμώξεις σε νεφρά και κύστη

TSH (thyroid stimulating hormone)

Checking the regulation of the thyroid gland and detecting possible hypothyroidism or hyperthyroidism, which causes symptoms of chronic fatigue.

Ferrum (Fe) and Ferritin (Ferr)

Ferrum deficiency can cause severe symptoms of fatigue. A possible diagnosis of ferrum deficiency requires further investigation. Ferrum deficiency is now common in women of childbearing age, as well as in older women.

Sodium, Potassium

The specific trace elements - electrolytes, regulate the body's water balance. By measuring them, we check possible dehydration or deregulation of electrolytes due to drugs (e.g. diuretics, anti-hypertensives, etc.).

ANA (antinuclear antibodies)

ANAs are a series of many different antibodies from different autoimmune diseases. They are usually expressed with long-term inflammations and the constant strain on the immune system, musculoskeletal pains, and chronic fatigue. They occur frequently among people with a family medical history of autoimmune disease, and it is more frequently in women.

Rheumatoid factor (RF)

Rheumatoid factor mainly detects rheumatoid arthritis, which is the autoimmune form of arthritis. Additional information can be given by the test, which is also sensitive to parasitic infections, tuberculosis, syphilis, and other autoimmune diseases, but also to diseases of the liver, kidneys, and lungs. All of the aforementioned conditions bring a chronic exhaustion to the body.

Optionally, the following tests are additionally done:

  1. Testosterone In cases of suspected hormonal disorder in men (restricted muscle growth / low sexual desire)
  2. Cortisol (Cort) In case of suspected adrenal dysfunction (fluid retention - sleep disorders)
  3. Celiac test In case of suspected intolerance to grains - gluten and with low values in Ferritin or vitamin B12
  4. Food intolerance test In bloating / dizziness after eating specific foods (e.g. cheese, fish, eggs, dairy, etc.)
  5. Sexually transmitted diseases

In case of the diagnostic analyzes do not give a diagnosis, we provide you with an assessment and an initial consultation on:

  1. Sleep Quality
  2. Social habits
  3. Diet
  4. Orthosomia and physical condition
  5. Psychology - Stress Management

Information selected - indicative with sources: Interpretation of Diagnostic Tests - J.Wallach and

The choice and explanation of the use of the analysis is the exclusive responsibility of your doctor

Edited by : Ioannis Grattisia Head of Laboratory / MSc Clinical Biochemistry - Molecular Biology

2022 - 2023

Biopathology Diagnostic Laboratory | Microbiological | Molecular | DNA | Ultrasonic | EOPYY – Clinic

Diagnostic: Director Biochemist I. Gratsia - Biopathologist I. Katsavochristos / M. Kolokouri - Radiologist S. Alagiannis

Doctors: General Practitioner X. Chrysanthaki - Endocrinologist E. Typhoxylou – Cardiologist A. Castanas - Neurologist C. Karagiorgis - Urologist K. Psyllias - Pulmonologist Zafiria Barbaressou

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