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Common Screening Conditions Cardiovascular Risk Markers



Analytical laboratory risk assessment for cardiovascular disease is mainly suggested to individuals with multiple (at least 2-3) cardiovascular risk factors

  1. Smokingkardiaggeiakos_kindinos
  2. Diabetes
  3. Hypertension
  4. Abdominal Fat
  5. Male
  6. Stress psychological – chemical
  7. Abdominal fat
  8. Family history with cardiovascular
  9. Personal history in thrombi – Thrombophilia
  10. Dyslipidemia
  11. Reduced motion


Lipidemic profile

The basic parameters of the lipidemic profile (Cholesterol HDL, LDL, Triglycerides, Total lipids) are used as an independent risk factor due to endogenous and dietary factors. Measurements should be evaluated with the other cardiovascular risk factors, as evaluation of  lipidemic profile results ​​obtained, differs significantly when the other risk factors are taken in account.

C-reactive protein of high sensitivity (hs-CRP):

General inflammation marker, which can detect a possible intravascular inflammation due to active atherosclerotic process.

Attention though should be given not to be used when any other inflammation or chronic desease exists, givig a high baseline CRP level and making difficult to intrpret results as a cardiovascular marker.

Ομοκυστεΐνη (Hcy):

Homocysteine ​​values ​​are associated with vascular epithelial damage and the risk of atheromatosis – embolism. Increased values ​​can also be measured in cases of vitamin B9 (folate) deficiency, obesity, general inflammation, smokers but also in people with the frequently observed gene mutation MTHFR 677. In all cases, elevated blood homocystein levels give a proportional risk to a cardiovascular episode.

Fibinogen (Fibr):

It is a blood coagulation factor, which increases in vascular inflammation. The values ​​are related to the possibility of a large thrombus formation. A frequent gene mutation fparticularly favors elevated blood levels and a proportional risk of a cardiovascular episode.

Gene risk assessment of thrombophilia 

It is the analysis of hereditary factors that cause a risk of thrombosis and is recommended mainly to people with a family history of strokes and pulmonary emboli.

It is proposed as a basic economic analysis that the four key gene mutations CVD-4 IVD, which include genes with the strongest correlation with cardiovascular diseases, are identified:

  • MHTFR (C677T) in cases of  omozygous and less inheterozygous mutations, homocystein increases significantly
  • β-fibrinogen (-455G / A) in cases of  omozygous and less inheterozygous mutations, fibtinogen increases significantly
  • Factor V Leiden (1619Α) in cases of  omozygous and less inheterozygous mutations, thrombophylia occurs
  • Prothrombin (G20210A )in cases of  omozygous and less inheterozygous mutations, thrombophylia occurs

There is also the full CVD-20 Research gene control   that includes the analysis of 20 genes. For more read on the relevant page 



Ultrasound – triplex, is the basic imaging test that detects atherosclerotic plaques, and increased blood flow due to vascular stenosis. The points checked as independent exams are:

  • heart
  • carotids


Information selected with sources:

  • Interpretation of Diagnostic Tests – J.Wallach

The selection of the examinations is done with absolutely individual criteria. The exact choice is the responsibility of your treating physician

Editor: John Gratis Lab Director / Clinical Biochemist

May 2019


Medical Tests performed with analytical systems and reagents


Recommendations -preparation for blood sampling :
  • A meal the previous night is mandatory.
  • The last meal should be taken up to 11-12 hours before blood sampling.
  • The evening meal is preferred to include the least possible animal fats.
  • No meal should be taken in the morning. Coffee without sugar and water are free.
  • Results for phenotype tests ( liid profile, CRP, homocystein and fibrinogen) are given within day
  • Results foe gene analysis are gven within 5-10 working days
  • Phenotype tests at special offer 52 Euros (original price 69 )
  • CVD 4 gene mutation panel  120 euros
  • CVD 20 gene mutation panel 180 euros

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