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BRCA1 BRCA2 Genes Breast Cancer

BRCA1 and BRCA2 (Breast Cancer) genes are tumor suppressors and repair damaged areas of DNA to avoid pathological changes in tissues. Their mutations are responsible for a significant increase in the likelihood of developing breast cancer.

Scientific studies report that:

  • Abnormal forms of BRCA1 and BRCA2 occur in approximately 10% of breast cancers.
  • Mutations in the BRCA1 gene present an overall risk of developing the disease at the level of 80% until 90 years old.
  • Mutations in BRCA1 have also been associated with ovarian cancer with an estimated risk of 55%.
  • BRCA2 also participates in its abnormal forms in tumorigenesis, with ovarian cancer's risk as high as 25%.
  • Mutations in the BRCA genes have been associated in men with breast and prostate cancer
  • Mutations in the BRCA genes have also been associated with pancreatic carcinomas, leukemia and lymphomas.

The gene analysis is recommended for high-risk individuals (carriers of pathogenic mutation - mutations) and depending on the results, the individual should (or should not) undergo genetic counseling and a strict clinical surveillance program with:

  • Clinical breast examination, every six months, from the age of 25, or annual mammography and/or MRI from the age of 25
  • The possible choice to undergo preventive mastectomy taking into account the age of possible diagnosis of breast cancer in the examinee herself or her family medical history
  • The possible choice of salpingo-oophorectomy in women who have already given birth

Simple blood collection at any time of the day (7.30-19.30) without any restrictions on food - medicines - diseases

Possibility of sending a sample For information contact 2106983222

Result in about 1 month

The private cost of the laboratory exam is 450 euros*.

The exam is not prescribed by EOPYY**

**In our center we have doctors with the right to prescribe EOPYY prescriptions

Information selected - indicative with sources: Interpretation of Diagnostic Tests - J.Wallach and

The choice and explanation of the use of the analysis is the exclusive responsibility of your doctor

Edited by : Ioannis Grattisia Head of Laboratory / MSc Clinical Biochemistry - Molecular Biology

April 2019

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